Statistical analysis was performed with the SPSS statistical software program (version 18.0; SPSS, Chicago, IL). All soft tissue changes were related to bony changes in the horizontal and vertical dimensions by means of analyses of the Pearson correlation coefficient. To check for statistical significance of quantitative variables the paired sample t-test was used. All data are expressed as mean values, denoting a P value of �� 0.05 as significant. The reliability of measurements and the errors of the method were determined by randomly selecting 30 cephalograms before and after surgery. The same investigator digitized cephalograms after 2 weeks. The standard deviation (SD) of error of each measurement was calculated by Dahlberg's formula (�� ��D2/2N); where D is the difference between the first and second measurements and N is the number of double determinations. S6 Kinase
RESULTS The sample consisted of 96 skeletal Class III patients (42 women, 54 men) with a mean age of 25 years LY294002 molecular weight
(SD = 8.4). The youngest patient was 16-years-old and the oldest one was 51-years-old at the time of surgery. Sagittal and vertical hard tissue changes The main surgical changes were the advancement of the maxilla with an increase of theSNA angle from 79.7�� (SD = 4.8)�C83�� (SD = 5) (P < 0.001) and a mandibular posterior movement with a decrease of the SNB angle from 83�� (SD = 5.5) 80.7�� (SD = 5). The Wits value increased by 7 mm (SD = 4) and was significant (P < 0.001). At the beginning of the treatment 49 patients had SNA between 80��C84��, 34 had SNA of less than 80�� and 13 had SNA of more than 84��. Postsurgically, 25 patients had SNA of 78��C84��, 19 had SNA less than 78�� and 52 patients had SNA of more than 84��. Out of 96 patients 22 had SNB of 78��C82�� before surgery, 16 had less than HER2 inhibitor
78�� and 58 had SNA of more than 84��. Postoperatively we measured SNB of 78��C80�� in 42, less than 78�� in 18 and of more than 82�� in 36 patients. The inclination of the maxilla relative to the cranial base changed from 7.2�� (SD = 4)�C8�� (SD = 5.1) and the mandible changed from 35.7�� (SD = 6.6) 36�� (SD = 6.3) postoperatively and was not significant [Tables ?[Tables11 and ?and22]. Table 1 Sagittal parameters Table 2 Vertical parameters Dental changes The angle between the upper central incisor and the SN plane decreased significantly from 106.7�� (SD = 8.8)�C104.9�� (SD = 8.6), while IMPA increased by 4.8�� (SD = 7.2) (P < 0.001) [Table 3]. Table 3 Dental parameters Soft tissue changes The distance from upper lip to E-line increased by 2.6 mm (SD = 3.9) after surgery (P < 0.001), while, the lower lip distance to E-line decreased slightly by 0.9 mm (SD = 3.2) (P < 0.01). Nasolabial angle was decreased by 9.5�� (SD = 9.4) after surgery (P < 0.001). The nose prominence also decreased from 18.2 mm (SD = 3.5)�C16.5 mm (SD = 3.3) [Table 4].