The steps of the patient work-up were studied in detail and are reported in days (d). The ��patient-related delay�� was defined as the time from the first (��index��) symptom to health-care professional contact. The ��referral delay�� was the time from referral by a general practitioner or private doctor to the patient actually meeting a neurologist. The ��neurological delay�� was defined as the time from meeting PD-L1 inhibitors
the first specialist (neurologist) to surgical consultation. From within the neurological (diagnostic) delay, a ��radiological delay�� can be separated, which is the time between referral to radiological investigation and performing the investigation that gave enough information for the surgeon to schedule the patient for operation. The radiological delay could also overlap with the ��surgical delay��, which was defined as the time from first surgical consultation to the actual operation. Within this surgical delay, details in the waiting time were analysed in further detail. In order to further evaluate the appropriateness of the CEAs performed, the patients were divided into specific groups identified from the large randomised trials�� sub-analyses. In this process, sex, grade of stenosis and delay from the index symptom to operation were used to classify the patients.9 Distributions of the continuous variables were studied and tested for normality. Univariate comparison between the groups was performed with www.selleckchem.com/products/MDV3100.html
Student��s t-test or Mann�CWhitney rank sum test for continuous variables, and with Pearson ��2 test for discrete variables. All statistical analyses used SPSS 17.0 (SPSS Inc., Chicago, IL, USA). Two-sided values of P?<?0.05 were considered significant. For multivariate analysis testing associations with CEA delay less than 2 weeks or one month, a model of logistic regression including potential confounders as identified by univariate analysis (P?��?0.20) was applied. The data are given as OR (95% CI) with the corresponding P-value. One hundred consecutive CEA operations for symptomatic ICA stenosis were identified. In one patient, carotid surgery was deferred at the day of the planned operation due to cardiac and pulmonary problems. <a href="http://www.selleckchem.com/products/gsk1120212-jtp-74057.html
">Trametinib During the same time period, 42 asymptomatic patients were operated (29.6% of all CEAs) and 10 patients were treated by carotid stenting, but not included in the present analysis. The index symptom was afx in 19 (19%), TIA in 21 (21%) and stroke in 46 (46%) patients. Among patients with stroke as the index symptom (n?=?46), 11 patients (23.9%) had mRS?��?3, that is, a major stroke at the time of surgery ( Table 1). Most of them, that is, eight patients (72.7%) had moderate disability (mRS 3). Two patients had moderately severe disability (mRS 4) and one patient was severely disabled (mRS 5) prior to CEA.